Research Projects
The effect of the peripheral circulation and endothelial function on exercise tolerance in subjects with type 2 diabetes mellitus
Summary:
The metabolic responses to exercise in Type 2 Diabetes Mellitus (T2DM) suggest that glucose concentrations, production and utilization are all abnormal during exercise in patients with T2DM compared to non-diabetic individuals partly due to attenuated skeletal muscle insulin sensitivity. Maximal oxygen consumption (VO2 max) has been consistently reported to be reduced in T2DM compared with non-diabetics of the same sex, age and activity levels and endothelial function has also been reported to be abnormal at rest, as well as during exercise, in adults with T2DM compared to non-diabetic people. The current study aims to investigate the effect of the peripheral circulation and endothelial function on exercise tolerance in subjects with T2DM
PI:
Research Team:
FE Lithander, Donal O Shea & Simon Green