Research Projects
Cellular mechanisms of insulin resistance and exercise resistance in early onset type 2 diabetes mellitus
Summary:
Early onset type 2 diabetes is becoming more prevalent, driven by the epidemic surge in the incidence of obesity. Prof Nolan and colleagues have recently shown that obese subjects with early onset Type 2 diabetes do not respond metabolically to a three-month aerobic exercise-training regime. Equally obese, but normal glucose tolerant, subjects of similar age did respond with a 20% increase in VO2max. This is an important finding with serious implications both for an understanding of the pathogenesis of early onset Type 2 diabetes and for the design of appropriate and effective treatments. The current study aims to investigate the cellular mechanisms of insulin resistance and exercise resistance in patients with early onset type 2 diabetes mellitus.
PI:
Research team:
D O Gorman, FE Lithander, D O Hanlon, D Cooper,
Funding:
European Federation for the Study of Diabetes